Breast Cancer Initiative- the three main themes of this Initiative are i) properties of normal and neoplastic breast cells, ii) the role of the stroma in tumor growth and cancer metastasis, and iii) clinical research activities leading to the development of novel diagnostics and therapies. This Initiative is composed of investigators from four LICR Branches (New York, São Paulo, Stockholm and Uppsala) and collaborators in Brazil, Germany, Italy, Spain, Sweden, Switzerland, and the UK and USA.